Levitt M, Mendlewicz J
Mod Probl Pharmacopsychiatry. 1975;10:89-98. doi: 10.1159/000397921.
Plasma DBH activity was studied in patients with affective illness (unipolar or bipolar) and in their families. We found diagnosis, mood state or lithium treatment did not modify plasma DBH activity. In family studies we found same-sex siblings to show significant correlations for plasma DBH activity regardless of diagnosis. Monozygotic twins had almost identical DBH activities; 4 pairs of monozygotic twins discordant for affective illness were concordant for DHB activity. The heritability estimate for plasma DBH activity is greater than 0.90, indicating a strong genetic influence. These studies reveal that affective illness does not modify plasma DBH activity and that familial factors play an important role in controlling plasma DBH activity.
我们研究了情感性疾病（单相或双相）患者及其家庭成员的血浆多巴胺β-羟化酶（DBH）活性。我们发现，诊断、情绪状态或锂盐治疗均不会改变血浆DBH活性。在家族研究中，我们发现同性兄弟姐妹的血浆DBH活性存在显著相关性，与诊断无关。同卵双胞胎的DBH活性几乎相同；4对患情感性疾病不一致的同卵双胞胎在DHB活性方面是一致的。血浆DBH活性的遗传度估计大于0.90，表明有很强的遗传影响。这些研究表明，情感性疾病不会改变血浆DBH活性，且家族因素在控制血浆DBH活性中起重要作用。
