Levitt M, Dunner D L, Mendlewicz J, Frewin D B, Lawlor W, Fleiss J L, Stallone F, Fieve R R
Psychopharmacologia. 1976 Mar 16;46(2):205-10. doi: 10.1007/BF00421393.
Plasma dopamine beta hydroxylase (DBH) activity was measured in patients with affective disorders and in their relatives. The groups studied had wide distributions of values for plasma DBH activity. No significant difference of plasma DBH activity was found between unipolar and bipolar patients, nor between patients given lithium or placebo. Exercise on a treadmill at 40 degrees or 10 degrees C elicited a different pattern of response for plasma DBH activity in three patients as compared to control subjects. In familial studies we found the values of plasma DBH activity to be almost identical in monozygotic twin pairs and quite similar in dizygotic twin pairs. All pairs, however, were discordant for affective illness. There was also a marked similarity of plasma DBH activity in 15 pairs of the same sex sibs discordant for affective illness. These studies suggest that the resting level of plasma DBH activity is not related to affective illness but is genetically determined.
对情感障碍患者及其亲属的血浆多巴胺β羟化酶（DBH）活性进行了测量。所研究的群体血浆DBH活性值分布广泛。在单相和双相情感障碍患者之间，以及服用锂盐或安慰剂的患者之间，未发现血浆DBH活性有显著差异。与对照组相比，三名患者在40摄氏度或10摄氏度的跑步机上运动时，血浆DBH活性的反应模式不同。在家族研究中，我们发现同卵双胞胎对的血浆DBH活性值几乎相同，异卵双胞胎对的则相当相似。然而，所有双胞胎对在情感疾病方面都不一致。在15对患情感疾病不一致的同性同胞中，血浆DBH活性也有明显相似性。这些研究表明，血浆DBH活性的静息水平与情感疾病无关，而是由基因决定的。
