慢性人类免疫缺陷病毒感染个体在结构化治疗中断期间的病毒进化
Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.
作者信息
Martinez-Picado Javier, Frost Simon D W, Izquierdo Nuria, Morales-Lopetegi K, Marfil Silvia, Puig Teresa, Cabrera Cecilia, Clotet Bonaventura, Ruiz Lidia
机构信息
IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain.
出版信息
J Virol. 2002 Dec;76(23):12344-8. doi: 10.1128/jvi.76.23.12344-12348.2002.
Abstract
We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.
摘要
我们分析了12名接受结构化治疗中断（STI）的慢性感染个体中1型人类免疫缺陷病毒（HIV-1）env基因的演变。长度变异分析和克隆序列分析显示出高度不可预测的演变，这可能会限制STI对HIV特异性免疫反应的增强，因为暴露于病毒抗原的变异性。
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