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本文引用的文献

1
Viral dynamics during structured treatment interruptions of chronic human immunodeficiency virus type 1 infection.慢性1型人类免疫缺陷病毒感染结构化治疗中断期间的病毒动力学。
J Virol. 2002 Feb;76(3):968-79. doi: 10.1128/jvi.76.3.968-979.2002.
2
MRBAYES: Bayesian inference of phylogenetic trees.MRBAYES：系统发育树的贝叶斯推断
Bioinformatics. 2001 Aug;17(8):754-5. doi: 10.1093/bioinformatics/17.8.754.
3
HIV dynamics and T-cell immunity after three structured treatment interruptions in chronic HIV-1 infection.慢性HIV-1感染中三次结构化治疗中断后的HIV动态变化与T细胞免疫
AIDS. 2001 Jun 15;15(9):F19-27. doi: 10.1097/00002030-200106150-00001.
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Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapy.通过抗病毒治疗对HIV-1的CXCR4特异性毒株进行优先抑制。
J Clin Invest. 2001 Feb;107(4):431-8. doi: 10.1172/JCI11526.
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Cellular immune responses and viral diversity in individuals treated during acute and early HIV-1 infection.急性和早期HIV-1感染期接受治疗的个体的细胞免疫反应和病毒多样性
J Exp Med. 2001 Jan 15;193(2):169-80. doi: 10.1084/jem.193.2.169.
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Human immunodeficiency virus type 1 quasi species that rebound after discontinuation of highly active antiretroviral therapy are similar to the viral quasi species present before initiation of therapy.在高效抗逆转录病毒治疗中断后反弹的1型人类免疫缺陷病毒准种与治疗开始前存在的病毒准种相似。
J Infect Dis. 2001 Jan 1;183(1):36-50. doi: 10.1086/317641. Epub 2000 Dec 8.
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Immune control of HIV-1 after early treatment of acute infection.急性感染早期治疗后HIV-1的免疫控制
Nature. 2000 Sep 28;407(6803):523-6. doi: 10.1038/35035103.
8
Genetic characterization of rebounding HIV-1 after cessation of highly active antiretroviral therapy.高效抗逆转录病毒治疗停止后反弹的HIV-1的基因特征分析
J Clin Invest. 2000 Oct;106(7):839-45. doi: 10.1172/JCI10565.
9
Enhancement of human immunodeficiency virus type 1-specific CD4 and CD8 T cell responses in chronically infected persons after temporary treatment interruption.在暂时中断治疗后，慢性感染个体中1型人类免疫缺陷病毒特异性CD4和CD8 T细胞反应增强。
J Infect Dis. 2000 Sep;182(3):766-75. doi: 10.1086/315748. Epub 2000 Aug 17.
10
Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy.既往病毒储存库与高效抗逆转录病毒治疗中断后血浆病毒血症再次出现之间的关系。
Nat Med. 2000 Jul;6(7):757-61. doi: 10.1038/77481.

慢性人类免疫缺陷病毒感染个体在结构化治疗中断期间的病毒进化

Viral evolution during structured treatment interruptions in chronically human immunodeficiency virus-infected individuals.

作者信息

Martinez-Picado Javier, Frost Simon D W, Izquierdo Nuria, Morales-Lopetegi K, Marfil Silvia, Puig Teresa, Cabrera Cecilia, Clotet Bonaventura, Ruiz Lidia

机构信息

IrsiCaixa Foundation, Hospital Germans Trias i Pujol, Universitat Autonoma de Barcelona, Badalona, Spain.

出版信息

J Virol. 2002 Dec;76(23):12344-8. doi: 10.1128/jvi.76.23.12344-12348.2002.

DOI:10.1128/jvi.76.23.12344-12348.2002
PMID:12414975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC136865/
Abstract

We analyzed the evolution of the human immunodeficiency virus type 1 (HIV-1) env gene in 12 chronically infected individuals who underwent structured treatment interruptions (STIs). Analyses of length variation and of clonal sequences demonstrated highly unpredictable evolution, which may limit the strengthening of HIV-specific immune responses by STIs because of the variability in exposure to viral antigens.

摘要

我们分析了12名接受结构化治疗中断（STI）的慢性感染个体中1型人类免疫缺陷病毒（HIV-1）env基因的演变。长度变异分析和克隆序列分析显示出高度不可预测的演变，这可能会限制STI对HIV特异性免疫反应的增强，因为暴露于病毒抗原的变异性。