Faix Peggy Ho, Feldman Steven A, Overbaugh Julie, Eiden Maribeth V
Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
J Virol. 2002 Dec;76(23):12369-75. doi: 10.1128/jvi.76.23.12369-12375.2002.
To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs is mediated primarily by the receptor binding domain; however, in the case of FeLV-B-90Z, the C terminus also contributes to the recognition of certain Pit1 orthologs.
为了评估两种不同的B亚群猫白血病病毒(FeLV-B)毒株之间的宿主范围差异,我们比较了携带FeLV-B-90Z或FeLV-B-GA包膜的逆转录病毒载体的结合和感染模式。我们在此报告,这些包膜利用不同Pit1直系同源物的能力主要由受体结合域介导;然而,对于FeLV-B-90Z,C末端也有助于识别某些Pit1直系同源物。