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携带猫白血病病毒B亚群包膜的载体的宿主范围和受体结合特性可通过受体结合域之外的包膜序列进行调节。

Host range and receptor binding properties of vectors bearing feline leukemia virus subgroup B envelopes can be modulated by envelope sequences outside of the receptor binding domain.

作者信息

Faix Peggy Ho, Feldman Steven A, Overbaugh Julie, Eiden Maribeth V

机构信息

Laboratory of Cellular and Molecular Regulation, National Institute of Mental Health, Bethesda, Maryland 20892, USA.

出版信息

J Virol. 2002 Dec;76(23):12369-75. doi: 10.1128/jvi.76.23.12369-12375.2002.

Abstract

To evaluate host range differences between two different strains of feline leukemia virus subgroup B (FeLV-B), we compared the binding and infectivity patterns of retrovirus vectors bearing either FeLV-B-90Z or FeLV-B-GA envelopes. We report here that the ability of these envelopes to utilize different Pit1 orthologs is mediated primarily by the receptor binding domain; however, in the case of FeLV-B-90Z, the C terminus also contributes to the recognition of certain Pit1 orthologs.

摘要

为了评估两种不同的B亚群猫白血病病毒(FeLV-B)毒株之间的宿主范围差异,我们比较了携带FeLV-B-90Z或FeLV-B-GA包膜的逆转录病毒载体的结合和感染模式。我们在此报告,这些包膜利用不同Pit1直系同源物的能力主要由受体结合域介导;然而,对于FeLV-B-90Z,C末端也有助于识别某些Pit1直系同源物。

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