Antal S, József B, József H, György D, Ferenc M, Gyula T
Magy Traumatol Orthop Helyreallito Seb. 1976;19(4):272-83.
In dog experiments homologous tendos conserved in beta-propiolacton and by means of gamma-radiation have been transplanted by the authors. After the 1st, 3rd and 8th post-operative week various regions of the graft and the recipient tendon stump have been examined by means of light--, polarisation microscopic and electron microscopic method. The examinations have unanimously shown that the tendon grafts conserved in beta-propiolacton are reorganized quickly, within 8 weeks nearly completely besides hardly visible inflammatory reaction. In the meantime, the originally collagen fibrous framework is decomposed and on it a new collagen fibrous structure develops, and thus a new tendon--capable to function--is formed. On the other hand, the reorganization of the grafts conserved with gamma-radiation is protracted or it fails to occur, and cicatrization is observed. Some problems of the modern tissue preservation, the collagen synthesis occurring in the active fibroblasts, the secretion of the collagen precursory substance into the extracellulary space, as well as the formation, the structure and the constitution of the newly synthesized collagen fibres--forming the transplant--are discussed by the authors. The obtained results are demonstrated in light-, polarization microscopic and electron microscopic pictures.
在犬类实验中，作者对用β-丙内酯保存并经γ射线辐射的同种异体肌腱进行了移植。在术后第1周、第3周和第8周，通过光学显微镜、偏振显微镜和电子显微镜方法对移植物和受体肌腱残端的各个区域进行了检查。检查结果一致表明，用β-丙内酯保存的肌腱移植物重组迅速，在8周内几乎完全重组，仅有轻微的炎症反应。与此同时，原来的胶原纤维框架被分解，在其上形成了新的胶原纤维结构，从而形成了一条能够发挥功能的新肌腱。另一方面，用γ射线辐射保存的移植物重组过程延长或未发生重组，观察到瘢痕形成。作者讨论了现代组织保存的一些问题，活跃成纤维细胞中发生的胶原合成，胶原前体物质分泌到细胞外空间的情况，以及形成移植物的新合成胶原纤维的形成、结构和组成。所获得的结果通过光学显微镜、偏振显微镜和电子显微镜图片展示。
