Salamon A, Bálint J
Handchirurgie. 1980;12(3-4):207-11.
In dog experiments homologous tendon grafts preserved in beta-propiolactone have been examined by means of light-polarisation microscope and electronmicroscope. The histologic data showed that grafts preserved by beta-propiolactone were completely reorganised within 8 weeks after the transplantation similarly to autologous grafts. This process takes place with very little initial inflammatory reaction, followed by fibroblast reaction. The original collagen fibrous framework is decomposed and new tendon is formed by new collagen fibres on this frame. Cicatrisation was not encountered and graft function was excellent. Functional results in 5 patients were investigated 2 years after replacement of the flexor tendons of the hand and were found to be good in 4 cases, satisfactory in 1 case. The results of animal experiments and the excellent experience with preliminary clinical application of the method suggest that homologous tendon grafts preserved in beta-propiolactone may be used for replacement of injured human flexor tendons of the hand.
在犬实验中，通过偏光显微镜和电子显微镜对保存在β-丙内酯中的同种异体肌腱移植物进行了检查。组织学数据显示，经β-丙内酯保存的移植物在移植后8周内完全重新组织，类似于自体移植物。这个过程在最初几乎没有炎症反应的情况下发生，随后是成纤维细胞反应。原来的胶原纤维框架被分解，新的肌腱在这个框架上由新的胶原纤维形成。未出现瘢痕形成，移植物功能良好。在手部屈肌腱置换术后2年对5例患者的功能结果进行了调查，发现4例良好，1例满意。动物实验结果以及该方法初步临床应用的良好经验表明，保存在β-丙内酯中的同种异体肌腱移植物可用于替代人类手部受伤的屈肌腱。
