Venkatachalam Kartik, van Rossum Damian B, Patterson Randen L, Ma Hong-Tao, Gill Donald L
Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Nat Cell Biol. 2002 Nov;4(11):E263-72. doi: 10.1038/ncb1102-e263.
The impact of calcium signalling on so many areas of cell biology reflects the crucial role of calcium signals in the control of diverse cellular functions. Despite the precision with which spatial and temporal details of calcium signals have been resolved, a fundamental aspect of the generation of calcium signals -- the activation of 'store-operated channels' (SOCs) -- remains a molecular and mechanistic mystery. Here we review new insights into the exchange of signals between the endoplasmic reticulum (ER) and plasma membrane that result in activation of calcium entry channels mediating crucial long-term calcium signals.
钙信号传导对细胞生物学诸多领域产生影响，这反映出钙信号在控制多种细胞功能方面的关键作用。尽管钙信号时空细节的解析已达到精确程度，但钙信号产生的一个基本方面——“储存式钙通道”（SOCs）的激活——在分子和机制层面仍是个谜。在此，我们综述了有关内质网（ER）与质膜之间信号交换的新见解，这些信号交换导致介导关键长期钙信号的钙内流通道被激活。
