Calcium Signaling Group, Weill Cornell Medicine Qatar, Doha 24144, Qatar.
College of Health and Life Science, Hamad bin Khalifa University, Doha 24144, Qatar.
Cells. 2021 May 19;10(5):1246. doi: 10.3390/cells10051246.
Ca signaling is ubiquitous in eukaryotic cells and modulates many cellular events including cell migration. Directional cell migration requires the polarization of both signaling and structural elements. This polarization is reflected in various Ca signaling pathways that impinge on cell movement. In particular, store-operated Ca entry (SOCE) plays important roles in regulating cell movement at both the front and rear of migrating cells. SOCE represents a predominant Ca influx pathway in non-excitable cells, which are the primary migrating cells in multicellular organisms. In this review, we summarize the role of Ca signaling in cell migration with a focus on SOCE and its diverse functions in migrating cells and cancer metastasis. SOCE has been implicated in regulating focal adhesion turnover in a polarized fashion and the mechanisms involved are beginning to be elucidated. However, SOCE is also involved is other aspects of cell migration with a less well-defined mechanistic understanding. Therefore, much remains to be learned regarding the role and regulation of SOCE in migrating cells.
钙信号在真核细胞中无处不在，调节许多细胞事件，包括细胞迁移。定向细胞迁移需要信号和结构元件的极化。这种极化反映在各种钙信号通路中，这些通路影响细胞运动。特别是，储存操作的钙内流（SOCE）在调节迁移细胞前后部的细胞运动中起着重要作用。SOCE 是无兴奋性细胞中的主要钙内流途径，无兴奋性细胞是多细胞生物中主要的迁移细胞。在这篇综述中，我们总结了钙信号在细胞迁移中的作用，重点介绍了 SOCE 及其在迁移细胞和癌症转移中的多种功能。SOCE 被认为以极化的方式调节粘着斑的周转率，并且所涉及的机制开始被阐明。然而，SOCE 还参与细胞迁移的其他方面，其机制理解较少。因此，关于 SOCE 在迁移细胞中的作用和调节仍有许多需要了解。
