从奥地利同一重症监护病房的两名患者中分离出的新型耐利奈唑胺粪肠球菌和屎肠球菌。
Emerging linezolid-resistant Enterococcus faecalis and Enterococcus faecium isolated from two Austrian patients in the same intensive care unit.
作者信息
Johnson A P, Tysall L, Stockdale M V, Woodford N, Kaufmann M E, Warner M, Livermore D M, Asboth F, Allerberger F J
机构信息
Antibiotic Resistance Monitoring and Reference Laboratory, Central Public Health Laboratory, Colindale, London NW9 5HT, UK.
出版信息
Eur J Clin Microbiol Infect Dis. 2002 Oct;21(10):751-4. doi: 10.1007/s10096-002-0807-0. Epub 2002 Sep 13.
Of two patients in the same intensive care unit who were treated with linezolid, one yielded linezolid-resistant Enterococcus faecalis, whereas the other yielded linezolid-resistant Enterococcus faecium. In each case, molecular typing indicated that the resistant isolates were related to linezolid-susceptible isolates from the same patient, but differed from them by the same G2576U ribosomal RNA mutation. This is the first clinical case report of emerging resistance to linezolid among Enterococcus faecalis and also the first report of resistance involving vancomycin-susceptible rather than vancomycin-resistant enterococci. The linezolid-resistant isolates showed cross-resistance to the experimental oxazolidinone AZD2563, suggesting that oxazolidinone resistance might be a class effect.
在同一重症监护病房接受利奈唑胺治疗的两名患者中，一名患者分离出耐利奈唑胺的粪肠球菌，而另一名患者分离出耐利奈唑胺的屎肠球菌。在每种情况下，分子分型表明，耐药菌株与来自同一患者的利奈唑胺敏感菌株相关，但因相同的G2576U核糖体RNA突变而与之不同。这是粪肠球菌中出现对利奈唑胺耐药的首例临床病例报告，也是涉及万古霉素敏感而非万古霉素耐药肠球菌耐药的首例报告。耐利奈唑胺菌株对实验性恶唑烷酮AZD2563表现出交叉耐药性，提示恶唑烷酮耐药可能是类效应。
Zotero 插件