希腊耐(linezolid)利福霉素肠球菌：流行病学特征。
Linezolid-resistant enterococci in Greece: epidemiological characteristics.
机构信息
Department of Microbiology, School of Medicine, University of Patras, Greece.
出版信息
Chemotherapy. 2011;57(3):181-5. doi: 10.1159/000326444. Epub 2011 Apr 6.
BACKGROUND
14 linezolid-resistant enterococci (6 Enterococcus faecium and 8 Enterococcus faecalis) collected during 2009 from patients hospitalized in intensive care units of different Greek hospitals were investigated.
METHODS
The mechanism of resistance to linezolid was determined by sequencing analysis of the domain V of 23S rDNA, while the clonal relatedness was defined by pulsed-field gel electrophoresis and multilocus sequence typing.
RESULTS
All linezolid-resistant enterococci carried the G2576T mutation. E. faecium belonged to the international epidemic clones ST16, ST17, ST203 and ST65, while all E. faecalis strains belonged to the ST28 clone.
CONCLUSIONS
The spread of common linezolid-resistant enterococcal clones in intensive care units located in different areas of Greece emphasizes the importance of application of infection control measures to prevent the spread of such strains.
背景
2009 年从希腊不同医院重症监护病房住院患者中收集到 14 株耐利奈唑胺肠球菌（6 株屎肠球菌和 8 株粪肠球菌）。
方法
通过测序分析 23S rDNA 结构域 V 来确定对利奈唑胺的耐药机制，而通过脉冲场凝胶电泳和多位点序列分型来定义克隆相关关系。
结果
所有耐利奈唑胺肠球菌均携带 G2576T 突变。屎肠球菌属于国际流行克隆 ST16、ST17、ST203 和 ST65，而所有粪肠球菌菌株均属于 ST28 克隆。
结论
耐利奈唑胺肠球菌常见克隆在分布于希腊不同地区的重症监护病房中的传播，强调了应用感染控制措施来防止此类菌株传播的重要性。
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