Kajimoto Shintaro, Tanaka Takaya, Hirakawa Akihiko, Shinya Hiroshi, Matsuo Nobuaki, Nakatani Toshio
Department of Emergency and Critical Care Medicine, Kansai Medical University.
Chudoku Kenkyu. 2002 Jul;15(3):293-6.
A thirty-eight year old man took about 180 tablets of Seirogan. He was unconscious and had dyspnea with dark brown urine on admission. He recovered gradually after initial treatment. Seirogan contains a phenolic component. Symptoms and signs of poisoning are unconsciousness, convulsion, digestive tract disorder, pulmonary edema, hepatic failure, renal failure, and miosis. Clinical features include dark brown urine. On day 7, he again showed signs of creosote poisoning: relapse of unconsciousness and dark colored urine. Plasma concentration of phenol determined on the day before the relapse was much higher than that expected from the half-life of blood phenol. It is reported that Creosote poisoning results in a decrease in the intestinal peristalsis, or paralytic ileus. We would like to emphasize that a relapse of Creosote poisoning may occur due to possible delayed absorption of the Seirogan tablets.
一名38岁男子服用了约180片泻痢停。入院时他昏迷不醒，呼吸困难，伴有深棕色尿液。经过初步治疗后，他逐渐康复。泻痢停含有一种酚类成分。中毒的症状和体征包括昏迷、抽搐、消化道紊乱、肺水肿、肝衰竭、肾衰竭和瞳孔缩小。临床特征包括深棕色尿液。在第7天，他再次出现了木馏油中毒的症状：意识再次丧失和尿液颜色变深。复发前一天测定的血浆苯酚浓度远高于根据血中苯酚半衰期预期的浓度。据报道，木馏油中毒会导致肠道蠕动减弱，即麻痹性肠梗阻。我们想强调的是，泻痢停片剂可能存在吸收延迟，从而可能导致木馏油中毒复发。
