Frost Simon D W
Department of Pathology, School of Medicine, University of California, San Diego, USA.
AIDS Rev. 2002 Jul-Sep;4(3):119-27.
Our understanding of the way in which HIV responds to highly active antiretroviral therapy (HAART) has benefited greatly from the use of mathematical models of viral dynamics and evolution. In this paper, I review the role that these models may play in the design and analysis of studies of structured treatment interruptions (STIs). STIs are being investigated in several different contexts: to reduce drug toxicities; to boost HIV-specific immune responses; and to allow reversion of drug resistance mutations in highly drug-experienced patients. I illustrate how models can help to compare the dynamics and evolution of HIV in these different scenarios, and to assess the risks and benefits of STIs.
我们对人类免疫缺陷病毒（HIV）如何应对高效抗逆转录病毒疗法（HAART）的理解，很大程度上得益于病毒动力学和进化的数学模型的应用。在本文中，我将回顾这些模型在结构化治疗中断（STIs）研究的设计和分析中可能发挥的作用。目前正在多种不同背景下对结构化治疗中断进行研究：以降低药物毒性；增强HIV特异性免疫反应；以及使有丰富用药经验的患者体内的耐药突变发生逆转。我将举例说明模型如何有助于比较HIV在这些不同情况下的动力学和进化情况，并评估结构化治疗中断的风险和益处。
