McComsey Grace
Rainbow Babies and Children's Hospital, Case Western Reserve University Center for AIDS Research, Cleveland, Ohio, USA.
AIDS Rev. 2002 Jul-Sep;4(3):140-7.
The dramatic improvement seen in the latest years in the prognosis of HIV infection has been threatened by long-term toxicities of antiretroviral drugs. Nucleoside analogs remain the cornerstone of antiretroviral therapy, but these compounds seem to produce mitochondrial damage leading to a broad range of side effects, which depend of the organ/tissue affected. Among those toxicities are of particular concern lipoatrophy and hyperlactatemia syndromes. This review will focus on the pathogenesis of mitochondrion damage caused by nucleoside analogs and its clinical consequences, particularly in respect to body-shape changes.
近年来，抗逆转录病毒药物的长期毒性对HIV感染预后的显著改善构成了威胁。核苷类似物仍然是抗逆转录病毒治疗的基石，但这些化合物似乎会导致线粒体损伤，从而引发一系列广泛的副作用，这些副作用取决于受影响的器官/组织。其中，脂肪萎缩和高乳酸血症综合征尤其令人担忧。本综述将聚焦于核苷类似物引起的线粒体损伤的发病机制及其临床后果，特别是在体型变化方面。
