Gupta M, Bhargava M, Kumar S, Mittal M M
Int J Lepr Other Mycobact Dis. 1975 Oct-Dec;43(4):327-32.
In a group of 50 leprosy patients, platelet function tests were found to be abnormal in 44. More than half the patients showed significant impairment in platelet adhesiveness and aggregation to collagen which correlated best with increase in serum IgM levels. ADP-induced aggregation of platelets was not a major defect and Pf-3 availability was reduced only in a fourth of the patients. In vitro incubation of collagen with plasma from leprosy patients significantly reduced its ability to clump normal platelets. This appears to be the first report of defective platelet function in leprosy, and it is thought that such changes may in part be due to increased IgM globulins in the blood and/or to alterations in the collagen brought about thereby.
在一组50例麻风病患者中，发现44例血小板功能测试异常。超过半数的患者血小板对胶原蛋白的黏附性和聚集性显著受损，这与血清IgM水平升高最为相关。ADP诱导的血小板聚集不是主要缺陷，仅四分之一的患者血小板第3因子活性降低。麻风病患者血浆与胶原蛋白的体外孵育显著降低了其使正常血小板聚集的能力。这似乎是关于麻风病患者血小板功能缺陷的首次报告，据认为这种变化可能部分归因于血液中IgM球蛋白增加和/或由此导致的胶原蛋白改变。
