Division of Urology, Department of Surgery, Dr. Zainoel Abidin General Hospital, Universitas Syiah Kuala, Banda Aceh, Aceh, 23230, Indonesia.
Division of Urology, Department of Surgery, Dr. Hasan Sadikin General Hospital, Universitas Padjajaran, Bandung, Indonesia.
F1000Res. 2024 Feb 5;11:142. doi: 10.12688/f1000research.84355.3. eCollection 2022.
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was firstly identified in China and has been declared a global pandemic. Several serious extrapulmonary manifestations due to SARS-CoV-2 infection have also been reported and associated with hypercoagulability thrombotic vasculopathy. In addition, cases of infection have also been known associated with blood coagulation abnormality.
Here, we report a 56-year-old male with coronavirus disease-19 (COVID-19) with concomitant leprosy infection with manifestation of glans penile necrosis, presented to the emergency department with acute penile pain. This case is unique because no occlusion blood flow to the penile was observed in the radiographic imaging. We described the potential pathophysiology in this case through a literature review.
The patient received treatment according to the COVID-19 protocol and was given low molecular weight heparin (LMWH) therapy for 4 days. During the follow up, the clinical and functional condition of the penis showed significant improvement.
Microthrombus involvement, platelet abnormalities and impaired hemostasis due to SARS-CoV-2 and leprosy co-infection are the hypothesis in this case report.
严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染最初在中国被发现，并已被宣布为全球大流行。由于 SARS-CoV-2 感染还报道了几种严重的肺外表现，并与高凝性血栓性血管病变相关。此外，也有感染病例与凝血异常有关。
在这里，我们报告了一例 56 岁男性，患有冠状病毒病 19（COVID-19），同时患有麻风病感染，表现为阴茎龟头坏死，因急性阴茎疼痛到急诊科就诊。该病例很独特，因为在影像学检查中未观察到阴茎血流阻塞。我们通过文献复习描述了该病例的潜在病理生理学。
患者按照 COVID-19 方案进行治疗，并接受低分子肝素（LMWH）治疗 4 天。在随访期间，阴茎的临床和功能状况明显改善。
SARS-CoV-2 和麻风病合并感染导致微血栓形成、血小板异常和止血功能受损，这是本病例报告的假设。
