Shen Wen-Hui
Institut de Biologie Moléculaire des Plantes (IBMP), CNRS-ULP, 12 rue du Général Zimmer, 67084 Strasbourg, France.
Trends Plant Sci. 2002 Nov;7(11):505-11. doi: 10.1016/s1360-1385(02)02351-8.
Plants and animals use the E2F-Rb pathway as a major mechanism of control in the decision to continue or stop cell division. The E2F-Rb pathway controls the G1-to-S-phase transition by the timely activation of genes involved in DNA synthesis and cell-cycle control. Recent findings reveal that the E2F-Rb pathway communicates with chromatin-remodelling factors in the control of transcription and cell-cycle progression. This article highlights the fast-moving advances in the molecular and functional characterization of plant E2F proteins, and in our understanding of how the E2F-Rb pathway is activated and repressed.
植物和动物将E2F-Rb通路作为决定继续或停止细胞分裂的主要控制机制。E2F-Rb通路通过及时激活参与DNA合成和细胞周期控制的基因来控制G1期到S期的转换。最近的研究发现表明，E2F-Rb通路在转录控制和细胞周期进程中与染色质重塑因子相互作用。本文重点介绍了植物E2F蛋白在分子和功能特性方面的快速进展，以及我们对E2F-Rb通路如何被激活和抑制的理解。
