红细胞黏附/聚集试验（EAAT）。一种用于揭示具有动脉粥样硬化风险因素个体中低度亚临床隐匿性炎症存在的新型生物标志物。

The erythrocyte adhesiveness/aggregation test (EAAT). A new biomarker to reveal the presence of low grade subclinical smoldering inflammation in individuals with atherosclerotic risk factors.

作者信息

Rotstein Rivka, Landau Tali, Twig Abraham, Rubinstein Ardon, Koffler Michael, Justo Daniel, Constantiner Doron, Zeltser David, Shapira Itzhak, Mardi Tamar, Goldin Yelena, Berliner Shlomo

机构信息

Department of Internal Medicine 'D', Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.

出版信息

Atherosclerosis. 2002 Dec;165(2):343-51. doi: 10.1016/s0021-9150(02)00250-2.

DOI:10.1016/s0021-9150(02)00250-2

PMID:12417286

Abstract

BACKGROUND

Multiple acute phase proteins and atherosclerotic risk factors increase the aggregability of erythrocytes.

METHODS AND RESULTS

We used a simple slide test and image analysis to determine the degree of erythrocyte adhesiveness/aggregation in the peripheral blood of 222 women and 221 men with no, one, two or more atherosclerotic risk factors. The degree of erythrocyte adhesiveness/aggregation correlated significantly with the concentration of commonly used variables of the acute phase response. We also showed that individuals with low erythrocyte adhesiveness/aggregation tend to be younger and to have fewer risk factors for atherosclerosis, including diabetes mellitus, hypertension, hyperlipidemia and smoking.

CONCLUSIONS

The association between increased erythrocyte adhesiveness/aggregation, higher concentrations of acute phase proteins, and increased atherosclerotic risk factors points to a possible clinical applicability of the erythrocyte adhesiveness/aggregation test (EAAT) to reveal the presence of both low-grade subclinical smoldering inflammation and morbid biology in individuals with risk factors for atherosclerosis.

摘要

背景

多种急性期蛋白和动脉粥样硬化危险因素会增加红细胞的聚集性。

方法与结果

我们采用一种简单的玻片试验和图像分析方法，测定了222名女性和221名男性外周血中红细胞黏附/聚集程度，这些人无、有一个、两个或更多动脉粥样硬化危险因素。红细胞黏附/聚集程度与急性期反应常用变量的浓度显著相关。我们还发现，红细胞黏附/聚集程度低的个体往往更年轻，且患动脉粥样硬化的危险因素（包括糖尿病、高血压、高脂血症和吸烟）更少。