Rotstein Rivka, Landau Tali, Twig Abraham, Rubinstein Ardon, Koffler Michael, Justo Daniel, Constantiner Doron, Zeltser David, Shapira Itzhak, Mardi Tamar, Goldin Yelena, Berliner Shlomo
Department of Internal Medicine 'D', Tel Aviv Sourasky Medical Center, Tel Aviv, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, 6 Weizman Street, Tel Aviv 64239, Israel.
Atherosclerosis. 2002 Dec;165(2):343-51. doi: 10.1016/s0021-9150(02)00250-2.
Multiple acute phase proteins and atherosclerotic risk factors increase the aggregability of erythrocytes.
We used a simple slide test and image analysis to determine the degree of erythrocyte adhesiveness/aggregation in the peripheral blood of 222 women and 221 men with no, one, two or more atherosclerotic risk factors. The degree of erythrocyte adhesiveness/aggregation correlated significantly with the concentration of commonly used variables of the acute phase response. We also showed that individuals with low erythrocyte adhesiveness/aggregation tend to be younger and to have fewer risk factors for atherosclerosis, including diabetes mellitus, hypertension, hyperlipidemia and smoking.
The association between increased erythrocyte adhesiveness/aggregation, higher concentrations of acute phase proteins, and increased atherosclerotic risk factors points to a possible clinical applicability of the erythrocyte adhesiveness/aggregation test (EAAT) to reveal the presence of both low-grade subclinical smoldering inflammation and morbid biology in individuals with risk factors for atherosclerosis.
多种急性期蛋白和动脉粥样硬化危险因素会增加红细胞的聚集性。
我们采用一种简单的玻片试验和图像分析方法，测定了222名女性和221名男性外周血中红细胞黏附/聚集程度，这些人无、有一个、两个或更多动脉粥样硬化危险因素。红细胞黏附/聚集程度与急性期反应常用变量的浓度显著相关。我们还发现，红细胞黏附/聚集程度低的个体往往更年轻，且患动脉粥样硬化的危险因素（包括糖尿病、高血压、高脂血症和吸烟）更少。
红细胞黏附/聚集增加、急性期蛋白浓度升高与动脉粥样硬化危险因素增加之间的关联表明，红细胞黏附/聚集试验（EAAT）可能具有临床应用价值，可用于揭示动脉粥样硬化危险因素个体中低度亚临床隐匿性炎症和病态生物学的存在。
