Zilberman Liaz, Rogowski Ori, Rozenblat Meirav, Shapira Itzhak, Serov Jacob, Halpern Pinhas, Dotan Iris, Arber Nadir, Berliner Shlomo
Department of Medicine "D," Tel-Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Dig Dis Sci. 2005 Apr;50(4):677-83. doi: 10.1007/s10620-005-2556-2.
Chronic inflammation is associated with increased erythrocyte adhesiveness/aggregation. This might have deleterious effects on the microcirculatory flow and tissue oxygenation. We aimed to determine the degree of erythrocyte adhesiveness/aggregation in the peripheral blood of individuals with inflammatory bowel disease (IBD). Fifty-two patients (24 women and 28 men) with ulcerative colitis (UC) at a mean age of 44.0+/-16.8 years and 96 patients (44 women and 52 men) with Crohn's disease (CD) at a mean age of 38.0+/-15.5 years, with various degrees of disease activity, were matched to normal controls. A simple slide test and image analysis were used to determine the degree of erythrocyte adhesiveness/aggregation. CD activity index (CDAI) was determined in patients with CD, while clinical colitis activity index was applied for patients with UC. A significant (P < 0.0005) increment in the degree of erythrocyte adhesiveness/aggregation was noted in both groups of IBD patients compared with matched control groups. This increment was evident even in individuals with a low index of disease activity and during remission. The highly significant correlation with the concentrations of fibrinogen suggests that the degree of erythrocyte adhesiveness/aggregation is an inflammation-related phenomenon. An enhanced state of erythrocyte adhesiveness/aggregation was noted in the peripheral blood of patients with IBD. This might have a deleterious effect on intestinal microcirculatory flow and tissue oxygenation.
慢性炎症与红细胞黏附性/聚集性增加有关。这可能对微循环血流和组织氧合产生有害影响。我们旨在确定炎症性肠病（IBD）患者外周血中红细胞黏附性/聚集性的程度。52例溃疡性结肠炎（UC）患者（24例女性和28例男性），平均年龄44.0±16.8岁，以及96例克罗恩病（CD）患者（44例女性和52例男性），平均年龄38.0±15.5岁，疾病活动程度各异，与正常对照组进行匹配。采用简单玻片试验和图像分析来确定红细胞黏附性/聚集性的程度。对CD患者测定CD活动指数（CDAI），对UC患者应用临床结肠炎活动指数。与匹配的对照组相比，两组IBD患者的红细胞黏附性/聚集性程度均有显著（P<0.0005）增加。即使在疾病活动指数较低的个体以及缓解期，这种增加也很明显。与纤维蛋白原浓度的高度显著相关性表明，红细胞黏附性/聚集性程度是一种与炎症相关的现象。IBD患者外周血中红细胞黏附性/聚集性增强。这可能对肠道微循环血流和组织氧合产生有害影响。
