Avitsur Ronit, Stark Jennifer L, Dhabhar Firdaus S, Sheridan John F
Section of Oral Biology, The Ohio State University Health Sciences Center, Columbus, OH, USA.
J Neuroimmunol. 2002 Nov;132(1-2):66-71. doi: 10.1016/s0165-5728(02)00310-7.
Social stress of group-housed male mice induced a state of functional glucocorticoid (GC) resistance in splenocytes. The following studies examined the effects of paired-fighting (PF) stress on immune cell distribution and function in spleens of male mice. Following six daily PF stress sessions, splenic monocytes and neutrophils increased and lymphocytes decreased. PF also altered the distribution of CD62L and CD11b positive monocytes. Additionally, PF augmented proliferation and lowered the sensitivity of LPS-stimulated splenocytes to the antiproliferative effects of corticosterone, suggesting that PF induced a state of GC resistance in splenocytes. Together, these findings indicate that social stress altered phenotype and function of splenic immune cells. These findings may have implications for the healing of bite wounds that are often associated with social stress in rodents.
群居雄性小鼠的社会压力会在脾细胞中诱导出功能性糖皮质激素（GC）抵抗状态。以下研究考察了配对打斗（PF）应激对雄性小鼠脾脏中免疫细胞分布和功能的影响。经过为期六天的每日PF应激实验后，脾脏中的单核细胞和中性粒细胞增加，淋巴细胞减少。PF还改变了CD62L和CD11b阳性单核细胞的分布。此外，PF增强了增殖，并降低了脂多糖刺激的脾细胞对皮质酮抗增殖作用的敏感性，表明PF在脾细胞中诱导出了GC抵抗状态。这些发现共同表明，社会压力改变了脾脏免疫细胞的表型和功能。这些发现可能对啮齿动物中常与社会压力相关的咬伤伤口的愈合有影响。
