Engler Harald, Bailey Michael T, Engler Andrea, Sheridan John F
Laboratory of Neuroendocrine Immunology, Section of Oral Biology, College of Dentistry, The Ohio State University Health Sciences Center, Columbus, OH 43210, USA.
J Neuroimmunol. 2004 Mar;148(1-2):106-15. doi: 10.1016/j.jneuroim.2003.11.011.
Leukocyte trafficking between the various body compartments has an important surveillance function that ensures the detection of antigen and enables the immune system to initiate a rapid and effective response. Repeated social defeat of group-housed male mice induced by daily, acute encounters with an aggressive conspecific substantially altered leukocyte trafficking and led to a gradual redistribution of immune cells in bone marrow, peripheral blood and spleen. Recurrent exposure to the stressor over a period of 2, 4 or 6 consecutive days was associated with cell mobilization and increased myelopoiesis in the bone marrow that was paralleled by an accumulation of neutrophils and monocytes in circulation and spleen. Substantial depletion of B cells in bone marrow and blood was associated with an increase in splenic B cells indicating a redirection of this cell type to the spleen. In contrast, T cells were markedly reduced in these immune compartments. The recruitment of CD11b+ leukocytes (i.e., monocytes/macrophages and neutrophils) from the bone marrow to the spleen might play a critical role in the development of functional glucocorticoid resistance in the murine spleen that was reported in context with repeated social defeat.
白细胞在身体各个腔室之间的运输具有重要的监测功能，可确保对抗原的检测，并使免疫系统能够启动快速有效的反应。每天与具有攻击性的同种个体进行急性接触，对群居雄性小鼠造成反复的社会挫败，这会显著改变白细胞运输，并导致免疫细胞在骨髓、外周血和脾脏中逐渐重新分布。在连续2、4或6天的时间里反复暴露于应激源，与骨髓中的细胞动员和骨髓生成增加有关，同时循环系统和脾脏中的中性粒细胞和单核细胞也会积累。骨髓和血液中B细胞的大量减少与脾脏中B细胞的增加有关，表明这种细胞类型被重新导向脾脏。相比之下，这些免疫腔室中的T细胞明显减少。骨髓中CD11b⁺白细胞（即单核细胞/巨噬细胞和中性粒细胞）向脾脏的募集，可能在小鼠脾脏功能性糖皮质激素抵抗的发展中起关键作用，这一现象与反复的社会挫败有关。
