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癫痫流行病学——印度视角

Epidemiology of epilepsy--Indian perspective.

作者信息

Ray Biman Kanti, Bhattacharya Susanta, Kundu Tejendra Nath, Saha Shankar Prasad, Das Shyamal Kumar

机构信息

Department of Neuromedicine, Bangur Institute of Neurology, Kolkata.

出版信息

J Indian Med Assoc. 2002 May;100(5):322-6.

PMID:12418636
Abstract

There are about 20 epidemiological studies on epilepsy from different parts of India. They include both rural and urban studies. The prevalence rate stands at around 5/1000 population (at this rate present estimate of total epileptics in this country is about 5 million) and incidence rate varies from 38 to 49.3 per 100,000 population per year from two community-based studies in India. Case-control studies indicate that febrile seizures, family history of epilepsy and head trauma are significant risk factors. Type of seizure pattern showed maximum number of cases belonged to generalised seizures which is different from Western countries where partial seizure is the commonest variety. Treatment gap, which is a measure of per cent of patient populations not receiving the treatment, estimated to be up to 73.7% to 78% in India. Aetiology is unknown in about two-thirds of cases. Hot water epilepsy is unique in South India and single solitary ring enhancing lesion in brain imaging is a common feature in Indian subcontinent. Evaluation of prevalence study indicates that more case-control studies to find out the aetiology, pharmaco-economic study to find out the affordable drug for general public and mass health education should be undertaken to dispel the social stigma and to bring about change in the attitude about the disease.

摘要

印度不同地区有大约20项关于癫痫的流行病学研究。这些研究涵盖了农村和城市地区。患病率约为每1000人中有5例(按此比率估算,该国目前癫痫患者总数约为500万),而根据印度两项基于社区的研究,发病率为每年每10万人中有38至49.3例。病例对照研究表明,热性惊厥、癫痫家族史和头部外伤是重要的危险因素。发作模式类型显示,癫痫大发作的病例数最多,这与西方国家不同,在西方国家部分性发作是最常见的类型。治疗缺口是衡量未接受治疗的患者人群比例的指标,在印度估计高达73.7%至78%。约三分之二的病例病因不明。热水癫痫在印度南部很独特,脑成像中单个孤立的环形强化病灶是印度次大陆的一个常见特征。对患病率研究的评估表明,应开展更多病例对照研究以找出病因,开展药物经济学研究以找出适合普通大众的可负担药物,并进行大众健康教育,以消除社会污名,改变对该疾病的态度。

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