Wamsley Heather L, Alleman A Rick, Porter Michael B, Long Maureen T
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA.
J Am Vet Med Assoc. 2002 Nov 1;221(9):1303-5. doi: 10.2460/javma.2002.221.1303.
To evaluate CSF in horses with confirmed West Nile virus encephalomyelitis.
Retrospective study.
30 horses.
Results of CSF analyses from horses with acute neurologic signs attributed to West Nile virus infection that was confirmed by immunoglobulin M antibody capture ELISA were reviewed and analyzed.
Among 30 CSF samples, findings in 8 (27%) were within reference ranges and in 22 (73%) were abnormal. Among the 22 abnormal samples, mononuclear pleocytosis was found in 16 (73%) and high protein concentration with nucleated cell count within reference range was found in 6 (27%) samples. A predominance of lymphocytes was found in 11 of 16 samples with mononuclear pleocytosis, and a predominance of large mononuclear cells was found in 5 of 16 samples. Sensitivities of analyses of CSF obtained from the lumbosacral and atlanto-occipital regions of the spinal cord were 89 and 50%, respectively.
Results suggest that in horses with acute onset of neurologic signs caused by West Nile virus encephalomyelitis, findings in the CSF are likely to be abnormal, mononuclear pleocytosis with lymphocytic predominance may be most commonly observed, and CSF collected from the lumbosacral region may be abnormal more commonly than CSF collected from the atlanto-occipital region.
评估确诊为西尼罗河病毒脑脊髓炎的马匹的脑脊液情况。
回顾性研究。
30匹马。
对因西尼罗河病毒感染出现急性神经症状且经免疫球蛋白M抗体捕捉酶联免疫吸附测定确诊的马匹的脑脊液分析结果进行回顾和分析。
在30份脑脊液样本中，8份（27%）结果在参考范围内，22份（73%）异常。在22份异常样本中，16份（73%）出现单核细胞增多，6份（27%）样本蛋白质浓度高且有核细胞计数在参考范围内。16份单核细胞增多的样本中，11份以淋巴细胞为主，5份以大单核细胞为主。从脊髓腰骶部和寰枕部获取的脑脊液分析的敏感度分别为89%和50%。
结果表明，对于因西尼罗河病毒脑脊髓炎导致急性神经症状发作的马匹，脑脊液结果可能异常，最常观察到的可能是以淋巴细胞为主的单核细胞增多，且从腰骶部采集的脑脊液比从寰枕部采集的脑脊液更常出现异常。
