Oelze Michael L, Zachary James F, O'Brien William D
Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign, 61801, USA.
J Ultrasound Med. 2002 Nov;21(11):1201-10. doi: 10.7863/jum.2002.21.11.1201.
To estimate the average scatterer properties from ultrasonic backscatter in tissues for evaluating differences between neoplastic and healthy tissues.
Parametric images of 8 retired breeder rats in which spontaneous mammary tumors had developed were created by superimposing color-coded pixels related to the estimated average scatterer properties on conventional gray scale B-mode images.
The images showed a distinct difference between the tumors and surrounding healthy tissues. Analysis of the average scatterer diameters and acoustic concentrations showed a statistically significant difference (P < .05) between estimates inside and outside the tumors for most of the cases. Scatterer sizes inside the tumors were on average 30% larger than scatterer sizes in surrounding normal tissues. A feature analysis plot showed that there was a distinct difference between results obtained inside and outside the tumors.
Parametric imaging that uses estimates of scatterer properties in tissues may lead to detection and characterization (diagnosis) of diseased tissues on conventional sonographic scanning systems.
通过组织中的超声背散射估计平均散射体特性，以评估肿瘤组织与健康组织之间的差异。
通过将与估计的平均散射体特性相关的彩色编码像素叠加在传统灰阶B模式图像上，为8只已发生自发性乳腺肿瘤的退役繁殖大鼠创建参数图像。
图像显示肿瘤与周围健康组织之间存在明显差异。对平均散射体直径和声浓度的分析表明，在大多数情况下，肿瘤内部和外部的估计值之间存在统计学上的显著差异（P < 0.05）。肿瘤内部的散射体尺寸平均比周围正常组织中的散射体尺寸大30%。特征分析图显示，肿瘤内部和外部获得的结果存在明显差异。
利用组织中散射体特性估计的参数成像可能会在传统超声扫描系统上实现对病变组织的检测和特征描述（诊断）。
