Kwon Ohyun, Park Seung Bum, Schreiber Stuart L
Department of Chemistry and Chemical Biology, Howard Hughes Medical Institute, Harvard Institute of Chemistry and Cell Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
J Am Chem Soc. 2002 Nov 13;124(45):13402-4. doi: 10.1021/ja028086e.
We report the synthesis and arraying of 29 400 structurally diverse and complex polycyclic carbocycles using diversity-oriented synthesis (DOS) and the "one bead-one stock solution" technology platform. Skeletal diversity, a difficult challenge in DOS, was achieved with a branching reaction pathway using one or two Diels-Alder reactions. This pathway yields small molecules having 10 different skeletons.
我们报道了使用多样性导向合成（DOS）和“一珠一储备溶液”技术平台合成并排列29400个结构多样且复杂的多环碳环化合物。在DOS中，通过使用一个或两个狄尔斯-阿尔德反应的分支反应途径实现了骨架多样性这一艰巨挑战。该途径产生具有10种不同骨架的小分子。
