Chen Tielou, Lin Shilong, Liu Jingchang, Xu Bing, Hai Jiao, Tang Dahai
Department of Periodontal, Stomatological Research Center of Navy Hospital 411, Shanghai 200081, China.
Zhonghua Kou Qiang Yi Xue Za Zhi. 2002 May;37(3):228-30.
To study the effects and the therapeutic mechanism of hyperbaric oxygen (HBO) on prostaglandin E(2) (PGE(2)) in alveolar bone and gingiva of experimental periodontitis in animal.
Experimental periodontitis was produced by silk thread sutures combined with high content sugar diet. For HBO therapy, they were exposed to a pressure of 0.25 MPa (2.5ATA), breathing pure oxygen one session a day for 60 min. The treatment course was 2 weeks. The value of PGE(2) in gingiva and alveolar bone was analyzed by enzyme immunoassay (EIA).
The value of PGE(2) in gingiva of control group was 3.21 ng/g, and that of PGE(2) in alveolar bone was 3.22 ng/g. The contents of PGE(2) in gingiva (13.96 ng/g) and alveolar bone (13.32 ng/g) of periodontitis group increased markedly than control group (P < 0.01). The contents of PGE(2) in gingiva (5.21 ng/g) of HBO group were 62.7% which was lower than that of periodontitis group, and the value of PGE(2) in alveolar bone (4.05 ng/g) were 69.6% lower than that of periodontitis group. The difference of PGE(2) in gingiva or alveolar bone was significant for the HBO group and periodontitis group (P < 0.01).
The contents of PGE(2) in alveolar bone and gingiva increased markedly when experimental periodontitis has formed. The value of PGE(2) in alveolar bone and gingiva reduce markedly after HBO exposure, and the decreased rate of PGE(2) in alveolar bone is more evident than that of PGE(2) in gingiva after HBO therapy.
研究高压氧（HBO）对实验性牙周炎动物牙槽骨和牙龈中前列腺素E2（PGE2）的影响及其治疗机制。
采用丝线结扎联合高糖饮食法制备实验性牙周炎模型。HBO治疗组动物置于0.25MPa（2.5ATA）压力舱内，每日1次，吸纯氧60分钟，疗程2周。采用酶联免疫吸附测定法（EIA）检测牙龈和牙槽骨中PGE2含量。
对照组牙龈中PGE2含量为3.21ng/g，牙槽骨中PGE2含量为3.22ng/g。牙周炎组牙龈中PGE2含量（13.96ng/g）和牙槽骨中PGE2含量（13.32ng/g）较对照组显著升高（P<0.01）。HBO治疗组牙龈中PGE2含量（5.21ng/g）较牙周炎组降低62.7%，牙槽骨中PGE2含量（4.05ng/g）较牙周炎组降低69.6%。HBO治疗组与牙周炎组牙龈和牙槽骨中PGE2含量差异有统计学意义（P<0.01）。
实验性牙周炎形成时，牙槽骨和牙龈中PGE2含量显著升高。HBO治疗后，牙槽骨和牙龈中PGE2含量显著降低，且牙槽骨中PGE2含量降低率较牙龈更明显。
