辛蒲汤对肥大细胞介导的过敏反应的影响。

Effect of Sinpo-Tang on the mast cell-mediated anaphylactic reactions.

作者信息

Jeong Hyun Ja, Yi Jin Mu, Hong Seung Heon, Kong Joo Young, Kim Kyung Suk, Won Jin Hee, Cho Kwang Ho, Shin Tae Yong, Kim Ha Song, Kim Hyung Min

机构信息

College of Pharmacy, Wonkwang University, KI Co. Ltd., Iksan, Jeonbuk 570-749, South Korea.

出版信息

Pharmacol Res. 2002 Nov;46(5):453-8. doi: 10.1016/s1043661802002037.

DOI:10.1016/s1043661802002037

PMID:12419650

Abstract

The herbal formulation Sinpo-Tang (SPT) has long been used for various allergic diseases. We investigated the effect of SPT on the mast cell-mediated anaphylactic reactions in vivo and in vitro murine models. SPT dose dependently inhibited compound 48/80-induced ear swelling response and histamine release. SPT (0.001-0.1g/kg) significantly inhibited passive cutaneous anaphylaxis (PCA). The mast cell number was markedly decreased at the SPT-treated PCA site. In addition, SPT decreased intracellular calcium levels of activated mast cells. These results suggest that SPT inhibit the anaphylactic degranulation of mast cells through decrease of the intracellular calcium level.

摘要

草药配方辛朴汤（SPT）长期以来一直用于治疗各种过敏性疾病。我们研究了SPT对体内外小鼠模型中肥大细胞介导的过敏反应的影响。SPT剂量依赖性地抑制了化合物48/80诱导的耳部肿胀反应和组胺释放。SPT（0.001 - 0.1g/kg）显著抑制被动皮肤过敏反应（PCA）。在SPT处理的PCA部位，肥大细胞数量明显减少。此外，SPT降低了活化肥大细胞的细胞内钙水平。这些结果表明，SPT通过降低细胞内钙水平抑制肥大细胞的过敏脱颗粒。