Dall'Acqua Stefano, Innocenti Gabbriella, Viola Giampietro, Piovan Anna, Caniato Rosy, Cappelletti Elsa Mariella
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Italy.
Chem Pharm Bull (Tokyo). 2002 Nov;50(11):1499-501. doi: 10.1248/cpb.50.1499.
To search for antitumor agents from plants, we studied Polygala vulgaris since cytotoxic lignans are known to occur in some Polygala species. Preliminary data on plant petrol ether, chloroform, and methanol extracts from the roots and aerial parts, showed in vitro cytotoxic activity against the solid tumor LoVo cell line. Fractionation of the active extracts led to the isolation of three new compounds, a derivative of aucuparine and two xanthones, as well as a known methylsinapate. All compounds were tested for in vitro cytotoxic activity using two cell lines, LoVo and its strain, which express resistance to common antitumor agents.
为了从植物中寻找抗肿瘤药物，我们研究了黄花远志，因为已知某些远志属植物中含有具有细胞毒性的木脂素。对该植物根和地上部分的石油醚、氯仿和甲醇提取物的初步数据显示，其对实体瘤LoVo细胞系具有体外细胞毒性活性。对活性提取物进行分离，得到了三种新化合物、一种奥古品衍生物、两种氧杂蒽酮以及一种已知的甲基芥子酸盐。使用LoVo及其对常见抗肿瘤药物具有抗性的菌株这两种细胞系，对所有化合物进行了体外细胞毒性活性测试。
