Dall'Acqua Stefano, Viola Giampietro, Cappelletti Elsa Mariella, Innocenti Gabbriella
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Padova, Padova, Italy.
Z Naturforsch C J Biosci. 2004 May-Jun;59(5-6):335-8. doi: 10.1515/znc-2004-5-608.
Bioactivity-guided fractionation of Polygala alpestris L. (Rchb.) extracts led to the identification of two new xanthones, 1,3,7-trihydroxy-2,6-dimethoxyxanthone (1) and 2,3-methylenedioxy-4,7-dihydroxyxanthone (2). In addition five known compounds 3,4-dimethoxy-1,7-dihydroxyxanthone (3), 1,3-dihydroxy-7-methoxyxanthone (4), 1,7-dihydroxy-2,3-dimethoxyxanthone (5), 3',6-O-disinapoyl sucrose (6) and 3',5'-dimethoxybiphenyl-4-olo (7) were isolated. The structures of the isolated compounds were established by means of high resolution mass spectrometry, mono- and bi-dimensional NMR spectroscopy. All isolated compounds were tested for cytotoxic activity against three tumor cell lines (LoVo, HL-60, K 562).
对阿尔卑斯远志（Polygala alpestris L. (Rchb.)）提取物进行生物活性导向的分离，鉴定出两种新的氧杂蒽酮，即1,3,7-三羟基-2,6-二甲氧基氧杂蒽酮（1）和2,3-亚甲二氧基-4,7-二羟基氧杂蒽酮（2）。此外，还分离出了5种已知化合物，3,4-二甲氧基-1,7-二羟基氧杂蒽酮（3）、1,3-二羟基-7-甲氧基氧杂蒽酮（4）、1,7-二羟基-2,3-二甲氧基氧杂蒽酮（5）、3',6-O-二芥子酰蔗糖（6）和3',5'-二甲氧基联苯-4-醇（7）。通过高分辨率质谱、一维和二维核磁共振光谱确定了分离出的化合物的结构。对所有分离出的化合物针对三种肿瘤细胞系（LoVo、HL-60、K 562）进行了细胞毒性活性测试。
