Wang Dan, Gao Feng
Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agricultural University, No, 211, Huiming Road, Wenjiang Region, Chengdu, 611130, P, R, China.
Chem Cent J. 2013 Jun 3;7(1):95. doi: 10.1186/1752-153X-7-95.
Owing to the significant biological activities, quinazoline derivatives have drawn more and more attention in the synthesis and bioactivities research. This review summarizes the recent advances in the synthesis and biological activities investigations of quinazoline derivatives. According to the main method the authors adopted in their research design, those synthetic methods were divided into five main classifications, including Aza-reaction, Microwave-assisted reaction, Metal-mediated reaction, Ultrasound-promoted reaction and Phase-transfer catalysis reaction. The biological activities of the synthesized quinazoline derivatives also are discussed.
由于喹唑啉衍生物具有显著的生物活性，它们在合成及生物活性研究方面受到了越来越多的关注。本综述总结了喹唑啉衍生物在合成及生物活性研究方面的最新进展。根据作者在研究设计中采用的主要方法，这些合成方法主要分为五类，包括氮杂反应、微波辅助反应、金属介导反应、超声促进反应和相转移催化反应。同时也讨论了合成的喹唑啉衍生物的生物活性。
