用面包酵母酸性甘露聚糖组分处理的小鼠库普弗细胞白细胞介素-1活性的产生

Production of interleukin-1 activity of Kupffer cells from mice treated with the acidic mannan fraction of baker's yeast.

作者信息

Okawa Yoshio, Abe Kouji, Watanabe Toshihiko, Sasaki Hiroyoshi, Suzuki Masuko

机构信息

Second Department of Hygienic Chemistry, Tohoku Pharmaceutical University,miyagi, Japan.

出版信息

Biol Pharm Bull. 2002 Nov;25(11):1506-8. doi: 10.1248/bpb.25.1506.

DOI:10.1248/bpb.25.1506

PMID:12419972

Abstract

We investigated the production of interleukin-1 (IL-1) activity by Kupffer cells (KC) from mice treated with a neutral mannan fraction (WNM) or an acidic mannan fraction (WAM025) from baker's yeast (Saccharomyces cerevisiae) in vivo and in vitro. The mice administered WAM025 showed an increase in the number of KC and the IL-1 production compared with mice administered WNM. In an in vitro stimulation assay using KC from a normal mouse, it was also found that WAM025 displayed an increase in IL-1 production. Diisopropyl fluorophosphate completely inhibited the production of IL-1 by KC from the mice administered WAM025.

摘要

我们研究了用来自面包酵母（酿酒酵母）的中性甘露聚糖组分（WNM）或酸性甘露聚糖组分（WAM025）在体内和体外处理的小鼠的库普弗细胞（KC）产生白细胞介素-1（IL-1）活性的情况。与给予WNM的小鼠相比，给予WAM025的小鼠KC数量增加且IL-1产生增加。在使用正常小鼠的KC进行的体外刺激试验中，还发现WAM025使IL-1产生增加。二异丙基氟磷酸完全抑制了给予WAM025的小鼠的KC产生IL-1。