Okawa Y, Okura Y, Hashimoto K, Suzuki K, Suzuki S, Suzuki M
J Pharmacobiodyn. 1985 Nov;8(11):942-7. doi: 10.1248/bpb1978.8.942.
Protective activity of an acidic fraction of bakers' yeast mannan containing protein and phosphorus, designated as WAM025, against infection of Staphylococcus aureus beta H 248 strain in mice was investigated. WAM025 elicited a marked increase in the survival ratio of mice challenged with viable cells of the S. aureus strain, 5 X 10(8) cells per mouse, when the fraction was administered to mice 150 mg/kg/d, 5 times, intraperitoneally. This effect was stronger than that of WNM, a neutral fraction of mannan obtained from the same bakers' yeast. The difference seemed to correlate with the strength of activating effects of WAM025 and WNM on the reticuloendotherial system of the host animal. WAM025 induced higher activities of serum lysozyme and carbon clearance in mice than WNM. Also, mice treated with WAM025 showed a greater increase in number and activity of oxygen-generating blood polymorphonuclear leucocytes than mice treated with WNM.
研究了一种含有蛋白质和磷的面包酵母甘露聚糖酸性组分（命名为WAM025）对小鼠感染金黄色葡萄球菌βH 248菌株的保护活性。当以150mg/kg/d的剂量腹腔注射给小鼠5次时，WAM025显著提高了用每只小鼠5×10(8)个活细胞的金黄色葡萄球菌菌株攻击的小鼠的存活率。这种效果比从同一面包酵母中获得的甘露聚糖中性组分WNM更强。这种差异似乎与WAM025和WNM对宿主动物网状内皮系统的激活作用强度相关。WAM025比WNM诱导小鼠血清溶菌酶活性更高和碳清除能力更强。此外，与用WNM处理的小鼠相比，用WAM025处理的小鼠产氧血液多形核白细胞的数量和活性增加得更多。
