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早产时胎盘中谷胱甘肽依赖性抗氧化防御系统

Glutathione-dependent system of antioxidant defense in the placenta in preterm delivery.

作者信息

Prokopenko V M, Partsalis G K, Pavlova N G, Burmistrov S O, Arutyunyan A V

机构信息

D. O. Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, St. Petersburg.

出版信息

Bull Exp Biol Med. 2002 May;133(5):442-3. doi: 10.1023/a:1019845217485.

DOI:10.1023/a:1019845217485
PMID:12420055
Abstract

Components of the antioxidant defense system in placental tissues were studied in women with normal pregnancy and full-term delivery and women with spontaneous abortions at 28-36 weeks. In women with spontaneous abortions glutathione peroxidase activity in placental tissues increased and the content of SH compounds decreased, which led to exhaustion of the antioxidant defense system. Glutathione-S-transferase activity also decreased, which attests to impaired detoxifying function of the placenta.

摘要

对正常妊娠并足月分娩的女性以及在28 - 36周自然流产的女性胎盘组织中的抗氧化防御系统成分进行了研究。在自然流产的女性中,胎盘组织中的谷胱甘肽过氧化物酶活性增加,而SH化合物含量降低,这导致抗氧化防御系统耗竭。谷胱甘肽 - S - 转移酶活性也降低,这证明胎盘的解毒功能受损。

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