Decsi L, Nagy J
Acta Physiol Acad Sci Hung. 1975;46(1):71-8.
An objective and quantitative method has been developed for measuring the hyper-reactivity of septum-lesioned rats. Twenty drugs belonging to various classes have been investigated as to their influence on this hyper-reactivity. Seventeen compounds inhibited septal hyperreactivity. One drug (methylphenidate) augmented it, while metamphetamine and physostigmine were ineffective. It has been concluded that the use of septal rats in pharmacological investigations does not fulfil expectations. The model cannot differentiate between depressants of various kinds, antidepressants, narcotics or central cholinolytics any more than do the much more simple procedures routinely used in pharmacological laboratories.
已开发出一种客观定量的方法来测量隔区损伤大鼠的反应过度。对属于不同类别的20种药物对这种反应过度的影响进行了研究。17种化合物抑制了隔区反应过度。一种药物（哌醋甲酯）增强了反应过度，而甲基苯丙胺和毒扁豆碱则无效。得出的结论是，在药理学研究中使用隔区大鼠并不符合预期。该模型与药理学实验室常规使用的简单得多的程序一样，无法区分各类抑制剂、抗抑郁药、麻醉药或中枢抗胆碱药。
