Timofeeva S E, Voronina T A, Karaseva T L, Golovenko N Ia, Garibova T L
Farmakol Toksikol. 1986 Jul-Aug;49(4):13-5.
Acyl derivatives of crown esters containing amino acid derivatives as substitutes were studied. Derivatives of N-acylazacrown esters were found in experiments to display a broad spectrum of anticonvulsant activity, antiaggressive and tranquillizing effects and not to produce any sedative and myorelaxant actions. The profile of psychotropic activity of N-crown esters derivatives seems to be similar to that of atypic tranquillizers but the latters are less toxic.
对含有氨基酸衍生物作为取代基的冠醚酰基衍生物进行了研究。实验发现，N-酰基氮杂冠醚衍生物具有广泛的抗惊厥活性、抗攻击和镇静作用，且不产生任何镇静和肌松作用。N-冠醚衍生物的精神活性特征似乎与非典型镇静剂相似，但后者毒性较小。
