Krenska-Wiacek Anna, Szaflarska-Szczepanik Anna, Wysocki Mariusz
Katedra i Klinika Pediatrii, Alergologii i Gastroenterologii, AM im. L. Rydygiera w Bydgoszczy.
Pol Merkur Lekarski. 2002 Aug;13(74):107-10.
The immune system plays an important role in chronic gastroduodenitis. A group of 70 children with chronic gastroduodenitis were subjected to examinations, including 42 children with H. pylori infection (group I) and 28 children without H. pylori infection (group II). Applying the method of flow cytometry, the per cent values of peripheral blood lymphocytic subpopulations were determined before and after treatment. The obtained results of examinations in group I were compared with those obtained in group II and were also compared with the standards given by Zeman for healthy children. On the basis of analysis of own material it was found that in both studied groups before and after the treatment lower per cent values were observed of CD3 and CD8 T-cells, NK CD56 cells and higher value of CD4 to CD8 T-cell ratio was disclosed as compared to healthy children. Comparing the per cent values of lymphocytic subpopulations in children with and without H. pylori infection it was found that in group I a higher per cent of CD4 T-cells, lower per cent of CD8 T-cells and, therefore, higher value of CD4 to CD8 T-cell ratio were present.
免疫系统在慢性胃十二指肠炎症中发挥着重要作用。对一组70名患有慢性胃十二指肠炎症的儿童进行了检查，其中包括42名感染幽门螺杆菌的儿童（第一组）和28名未感染幽门螺杆菌的儿童（第二组）。采用流式细胞术方法，在治疗前后测定外周血淋巴细胞亚群的百分比值。将第一组的检查结果与第二组的结果进行比较，并与泽曼给出的健康儿童标准进行比较。基于对自身材料的分析发现，在两个研究组中，治疗前后与健康儿童相比，CD3和CD8 T细胞、NK CD56细胞的百分比值较低，CD4与CD8 T细胞比值较高。比较感染和未感染幽门螺杆菌儿童的淋巴细胞亚群百分比值发现，第一组中CD4 T细胞百分比更高，CD8 T细胞百分比更低，因此CD4与CD8 T细胞比值更高。
