Pannier M, Martinot V, Castède J C, Guitard J, Robert M, Le Touze A, Magalon G, Rives J M, Pinheiro L, Romana M C, Carlioz H, Debeugny P, Février P
Service des brûlés, hôpital Hôtel-Dieu, Nantes, France.
Ann Chir Plast Esthet. 2002 Aug;47(4):285-90. doi: 10.1016/s0294-1260(02)00122-x.
Split skin graft is frequently needed in the treatment of burned patients. Scalp is often free of burns. Due to its good skin quality and important surface, scalp is a very interesting skin donor site, specially in case of children. A controlled, randomised clinical trial was carried out in 10 French Plastic Surgery or Burns Units. It assessed the efficacy and the acceptability of calcium alginate dressing (Algosteril) versus paraffin gauze dressing (Jelonet) in the treatment of scalp donor sites in children. 67 children (mean age 54 months) entered the study, 34 in the alginate group and 33 in the control group. Follow-up visits were on day 2/d3, d5/d6, Day complete healing, d30 and d60 after surgery. The two groups were comparable on inclusion (demographic characteristics, burn nature and surface, donor site surface and thickness of split skin graft). The mean healing time was 10 and 11 days for Algosteril and Jelonet group respectively (ns). The quality of the newly formed tissue was estimated to permit a sooner skin reharvesting in the Algosteril group than in the control group (p = 0.003). Bleeding through dressing was significantly less important in the Algosteril group (p = 0.02). Changes were considered by investigators less painful with Algosteril on day complete healing (p = 0.0096). Hair growth is homogenous in both groups on day 30 and day 60 (ns). These results showed that scalp is a very interesting skin donor site and that Algosteril is of a real interest in donor site treatment.
在烧伤患者的治疗中，经常需要进行中厚皮片移植。头皮通常未被烧伤。由于其良好的皮肤质量和重要的体表位置，头皮是一个非常理想的皮肤供区，特别是对于儿童患者。在法国的10个整形外科或烧伤治疗中心进行了一项对照随机临床试验。该试验评估了藻酸钙敷料（Algosteril）与石蜡纱布敷料（Jelonet）在儿童头皮供区治疗中的疗效和可接受性。67名儿童（平均年龄54个月）参与了研究，藻酸钙敷料组34名，对照组33名。术后第2/3天、第5/6天、完全愈合日、第30天和第60天进行随访。两组在纳入时具有可比性（人口统计学特征、烧伤性质和面积、供区面积和中厚皮片厚度）。Algosteril组和Jelonet组的平均愈合时间分别为10天和11天（无统计学差异）。据估计，Algosteril组新形成组织的质量使得比对照组能更快再次取皮（p = 0.003）。Algosteril组敷料渗血明显较少（p = 0.02）。研究人员认为，在完全愈合日，使用Algosteril时换药引起的疼痛较轻（p = 0.0096）。在第30天和第60天，两组的头发生长均均匀（无统计学差异）。这些结果表明，头皮是一个非常理想的皮肤供区，且Algosteril在供区治疗中具有实际应用价值。
