Skerk V, Schönwald S, Krhen I, Markovinović L, Barsić B, Mareković I, Roglić S, Zeljko Z, Vince A, Cajić V
J Chemother. 2002 Aug;14(4):384-9. doi: 10.1179/joc.2002.14.4.384.
A total of 123 patients, older than 18 years of age, with symptoms of chronic prostatitis and inflammatory findings as well as the presence of Chlamydia trachomatis confirmed by DNA/RNA DIGENE hybridization method in expressed prostatic secretion or in voided bladder urine collected immediately after prostatic massage, were examined. The patients were randomized to receive a total of 4.5 g of azithromycin for 3 weeks, given as a 3-day therapy of 1 x 500 mg weekly or clarithromycin 500 mg b.i.d. for 15 days. Patients' sexual partners were treated at the same time. Clinical and bacteriological efficacy were evaluated 4-6 weeks after the end of therapy. In the group of patients with chronic chlamydial prostatitis the eradication rates (azithromycin 37/46, clarithromycin 36/45) and the clinical cure rates (azithromycin 32/46, clarithromycin 32/45) were not significantly different with regards to the administered drug (p > 0.05). In the group of patients with asymptomatic chlamydial prostatitis the eradication rates (azithromycin 11/16, clarithromycin 10/15) were not significantly different with regards to the administered drug (p = 1.00, OR = 1.1).
共检查了123例年龄大于18岁、有慢性前列腺炎症状及炎症表现、且通过DNA/RNA DIGENE杂交法在前列腺按摩后立即采集的前列腺分泌物或晨尿中确诊有沙眼衣原体的患者。患者被随机分为两组，一组接受为期3周共4.5克的阿奇霉素治疗，采用每周1次、每次500毫克、共3天的治疗方案；另一组接受克拉霉素治疗，500毫克，每日2次，共15天。患者的性伴侣同时接受治疗。在治疗结束后4至6周评估临床和细菌学疗效。在慢性衣原体前列腺炎患者组中，就所使用的药物而言，根除率（阿奇霉素组46例中37例，克拉霉素组45例中36例）和临床治愈率（阿奇霉素组46例中32例，克拉霉素组45例中32例）无显著差异（p>0.05）。在无症状衣原体前列腺炎患者组中，就所使用的药物而言，根除率（阿奇霉素组16例中11例，克拉霉素组15例中10例）无显著差异（p = 1.00，OR = 1.1）。
