Camargos M F, Stancek D, Rocha M A, Lessa L M, Reis J K P, Leite R C
Faculty of Veterinary Medicine, Federal University of Minas Gerais Av. Antĵnio Carlos, Belo Horizonte, Brazil.
J Vet Med B Infect Dis Vet Public Health. 2002 Sep;49(7):325-31. doi: 10.1046/j.1439-0450.2002.00582.x.
Analysis of the partial bovine leukaemia virus (BLV) env gp51 gene sequences obtained from three BLV strains isolated in three different regions of Brazil was carried out. The Brazilian BLV env gp51 sequences were compared with seven other corresponding sequences of BLV strains isolated in different countries and with consensus sequence as well. The obtained data point on qualitative and quantitative differences among the analysed strains as far as the occurrence of single point mutations is concerned. Two Brazilian strains show significantly higher mutation rate than other analysed strains. Amino acid analysis did not show, however, any substantial changes of the primary protein structure coded by well conserved region of BLV env gp51 gene. Based on the obtained data, the putative dendogram image of possible phylogenetic relations among the studied BLV strains is presented as well.
对从巴西三个不同地区分离出的三株牛白血病病毒（BLV）的env gp51基因部分序列进行了分析。将巴西BLV env gp51序列与在不同国家分离出的其他七株BLV菌株的相应序列以及共有序列进行了比较。就单点突变的发生情况而言，所获得的数据表明分析的菌株之间存在定性和定量差异。两株巴西菌株的突变率明显高于其他分析菌株。然而，氨基酸分析并未显示由BLV env gp51基因保守区域编码的一级蛋白质结构有任何实质性变化。基于所获得的数据，还呈现了所研究的BLV菌株之间可能的系统发育关系的推测树状图。
