Unidad de Biofísica de Proteínas, Institut Pasteur de Montevideo, Mataojo 2020, 11400 Montevideo, Uruguay.
Arch Virol. 2010 Apr;155(4):481-9. doi: 10.1007/s00705-010-0606-3. Epub 2010 Feb 19.
Bovine leukaemia virus (BLV) is an oncogenic member of the genus Deltaretrovirus of the family Retroviridae. Recent studies revealed that BLV strains can be classified into six different genotypes and raised the possibility that another genotype may exist. In order to gain insight into the degree of genetic variability of BLV strains circulating in the South American region, a phylogenetic analysis was performed using gp51 env gene sequences. The results of these studies revealed the presence of seven BLV genotypes in this geographic region and the suitability of partial gp51 env gene sequences for phylogenetic inference. A significant number of amino acid substitutions found in BLV strains isolated in South America map to the second neutralization domain of gp51. A 3D molecular model of BLV gp51 revealed that these substitutions are located on the surface of the molecule. This may provide a selective advantage to overcome immune host neutralization.
牛白血病病毒 (BLV) 是逆转录病毒科逆转录病毒属的一种致瘤成员。最近的研究表明，BLV 株可分为六种不同的基因型，并提出可能存在另一种基因型的可能性。为了深入了解在南美地区循环的 BLV 株的遗传变异程度，使用 gp51 env 基因序列进行了系统发育分析。这些研究的结果表明，在该地理区域存在七种 BLV 基因型，并且部分 gp51 env 基因序列适合用于系统发育推断。在南美的 BLV 株中发现的大量氨基酸取代位于 gp51 的第二个中和结构域。BLV gp51 的 3D 分子模型表明，这些取代位于分子的表面。这可能为克服宿主免疫的中和提供选择优势。
