Weiderpass Elisabete, Ye Weimin, Vainio Harri, Kaaks Rudolf, Adami Hans-Olov
International Agency for Research on Cancer, Lyon, France.
Cancer Causes Control. 2002 Oct;13(8):759-64. doi: 10.1023/a:1020271000069.
We present results from a large, population-based cohort study in Sweden, where we assessed ovarian cancer risk among patients hospitalized for diabetes mellitus.
The cohort was composed of patients identified in the Swedish In-Patient Register as having a hospital discharge diagnosis of diabetes mellitus in 1965-1994. The follow-up was done by linkages with the national cancer register and other population-based registers. Standardized incidence ratios (SIR) were used as a measure of relative risk.
After exclusion of the first year of follow-up (to avoid selection bias), 141,627 women remained in the cohort, contributing 865,746 years of follow-up to the study. The overall SIR for ovarian cancer was 0.97 (95% confidence interval (CI) 0.87-1.08). We found no difference in the risk estimates among women who had been hospitalized for classic complications of diabetes and for those who had not, or according to the duration of follow-up. Women above 40 years of age at first hospitalization presented a SIR of 0.96 (95% CI 0.85-1.07).
Our study provides evidence of lack of an association between diabetes mellitus and ovarian cancer.
我们展示了瑞典一项基于人群的大型队列研究的结果，在该研究中我们评估了因糖尿病住院患者的卵巢癌风险。
该队列由在瑞典住院登记册中确定的1965 - 1994年出院诊断为糖尿病的患者组成。通过与国家癌症登记册和其他基于人群的登记册建立联系进行随访。标准化发病率比（SIR）用作相对风险的衡量指标。
在排除随访的第一年（以避免选择偏倚）后，队列中仍有141,627名女性，为该研究贡献了865,746人年的随访数据。卵巢癌的总体标准化发病率比为0.97（95%置信区间（CI）0.87 - 1.08）。我们发现因糖尿病经典并发症住院的女性与未因该并发症住院的女性之间，以及根据随访时间长短划分的女性之间，风险估计没有差异。首次住院时年龄在40岁以上的女性标准化发病率比为0.96（95% CI 0.85 - 1.07）。
我们的研究提供了证据表明糖尿病与卵巢癌之间不存在关联。
