使用硼酸的电荷转移荧光探针用于单糖信号传导。
Charge transfer fluorescent probes using boronic acids for monosaccharide signaling.
作者信息
DiCesare Nicolas, Lakowicz Joseph R
机构信息
University of Maryland, Baltimore, Center for Fluorescence Spectroscopy, Department of Biochemistry and Molecular Biology, 725 W. Lombard St., Baltimore, Maryland, 21201, USA.
出版信息
J Biomed Opt. 2002 Oct;7(4):538-45. doi: 10.1117/1.1502263.
Abstract
We have developed a new series of glucose sensitive fluorophores that display shifts in emission wavelengths and/or intensity change upon the binding of monosaccharides. Complexation of glucose with the boronic acid moiety changes both its orbital hybridization and its ability to accept and donate electrons. This change results in distinct emission spectra for the fluorophores when free in solution or complexed with monosaccharide. The spectral changes upon saccharide binding can be modified by substitution of electron donor or acceptor group on the fluorophore allowing rational design of the spectral response.
摘要
我们已经开发出了一系列新型的葡萄糖敏感荧光团，它们在与单糖结合时会发生发射波长的移动和/或强度变化。葡萄糖与硼酸部分的络合改变了其轨道杂化以及接受和给予电子的能力。这种变化导致荧光团在溶液中游离或与单糖络合时具有不同的发射光谱。通过在荧光团上取代供电子或吸电子基团，可以改变糖类结合时的光谱变化，从而实现对光谱响应的合理设计。
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