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基于二硼烷酸的葡萄糖传感器的最新进展。

Recent Progress in Diboronic-Acid-Based Glucose Sensors.

机构信息

Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China.

School of Pharmaceutical Sciences, Cixi Biomedical Research Institute, Wenzhou Medical University, Wenzhou 325035, China.

出版信息

Biosensors (Basel). 2023 Jun 4;13(6):618. doi: 10.3390/bios13060618.

DOI:10.3390/bios13060618
PMID:37366983
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10296726/
Abstract

Non-enzymatic sensors with the capability of long-term stability and low cost are promising in glucose monitoring applications. Boronic acid (BA) derivatives offer a reversible and covalent binding mechanism for glucose recognition, which enables continuous glucose monitoring and responsive insulin release. To improve selectivity to glucose, a diboronic acid (DBA) structure design has been explored and has become a hot research topic for real-time glucose sensing in recent decades. This paper reviews the glucose recognition mechanism of boronic acids and discusses different glucose sensing strategies based on DBA-derivatives-based sensors reported in the past 10 years. The tunable p, electron-withdrawing properties, and modifiable group of phenylboronic acids were explored to develop various sensing strategies, including optical, electrochemical, and other methods. However, compared to the numerous monoboronic acid molecules and methods developed for glucose monitoring, the diversity of DBA molecules and applied sensing strategies remains limited. The challenges and opportunities are also highlighted for the future of glucose sensing strategies, which need to consider practicability, advanced medical equipment fitment, patient compliance, as well as better selectivity and tolerance to interferences.

摘要

具有长期稳定性和低成本的非酶传感器在葡萄糖监测应用中很有前景。硼酸（BA）衍生物为葡萄糖识别提供了一种可逆的和共价的结合机制，从而能够实现连续的葡萄糖监测和响应性胰岛素释放。为了提高对葡萄糖的选择性，已经探索了二硼酸（DBA）结构设计，并成为近几十年来实时葡萄糖传感的热门研究课题。本文综述了硼酸的葡萄糖识别机制，并讨论了过去 10 年基于 DBA 衍生物传感器的不同葡萄糖传感策略。探讨了苯硼酸的可调 p 电子、吸电子性质和可修饰基团，以开发各种传感策略，包括光学、电化学和其他方法。然而，与开发用于葡萄糖监测的众多单硼酸分子和方法相比，DBA 分子和应用的传感策略的多样性仍然有限。还强调了未来葡萄糖传感策略的挑战和机遇，这些策略需要考虑实用性、先进的医疗设备适配性、患者依从性，以及对干扰的更好选择性和耐受性。

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