High altitude pulmonary edema. A rare disease?

Since its original description in the English literature 15 years ago, high altitude pulmonary edema (HAPE) has been the subject of many reports. The clinical and hemodynamic features of HAPE are now well recognized, but its underlying pathophysiology remains unclear. In this article, a case of HAPE is described and the clinical features, proposed pathogenesis, and treatment are discussed. (JAMA 234:491-495, 1975).