Vishnevskiĭ B I, Narvskaia O V, Mokrousov I V, Istomin E A, Otten T F
Research Institute of Phtisiopulmonology, Ministry of Health of Russian Federation, Pasteur Research Institute of Epidemiology, St-Petersburg.
Antibiot Khimioter. 2002;47(6):31-3.
Susceptibility to levofloxacin of 56 strains of Mycobacterium tuberculosis, isolated from 22 patients with first estimated and 84 patients with chronic tuberculosis was investigated. Ratio of multi-drug resistance achieved 54.5 per cent in first group and 94.1 per cent in the second group. 23 (41.1 per cent) isolated strains belonged to individual genotypes, 33 (58.9 per cent)--to Beijing group. All mycobacteria isolates were sensitive to critical concentration of levofloxacin--10 mcg/mL. The results of the investigation proves the ability to recommend levofloxacin application at the patients with first estimated tuberculosis and at the patients with most hazardous tuberculosis pathogen of Beijing group.
对从22例初诊结核病患者和84例慢性结核病患者中分离出的56株结核分枝杆菌进行了左氧氟沙星敏感性研究。第一组的多重耐药率为54.5%，第二组为94.1%。23株（41.1%）分离菌株属于个别基因型，33株（58.9%）属于北京基因型。所有分枝杆菌分离株对左氧氟沙星的临界浓度10 mcg/mL敏感。研究结果证明，对于初诊结核病患者以及感染最危险的北京基因型结核病菌的患者，有理由推荐使用左氧氟沙星。
