Vishnevskiĭ B I, Istomin E A, Miakotina E N
Research Institute of Phtisiopulmonology, Ministry of Health of Russian Federation, St-Petersburg.
Antibiot Khimioter. 2002;47(6):28-30.
Susceptibility of 92 strains of mycobacteria to levofloxacin (5, 10 and 50 mcg/mL) was investigated by indirect method of absolute concentrations on Levenstain-Jensen media. The investigation was performed on 85 strains of Mycobacterium tuberculosis isolated from 83 patients with different types of tuberculosis and also on drug-sensitive laboratory strains of M. tuberculosis H37Rv-M, H37Rv-GISK, Academia, M. bovis-bovinus 8, M. bovis BCG and on two strains of M. fortuitum with total resistance to antimycobacterial agents. 87.8 per cent of clinical isolates were multi-drug resistant. From one patient treated with ciprofloxacin two strains of M. tuberculosis were isolated--one resistant to 5 mcg/mL of levofloxacin and second strain-resistant to 10 mcg/mL of levofloxacin. All other clinical and laboratory strains of mycobacteria (97.8 per cent) were susceptible to all three concentrations of levofloxacin.
采用绝对浓度间接法在罗-琴培养基上研究了92株分枝杆菌对左氧氟沙星（5、10和50微克/毫升）的敏感性。对从83例不同类型结核病患者中分离出的85株结核分枝杆菌以及结核分枝杆菌H37Rv-M、H37Rv-GISK、学术型、牛型结核分枝杆菌8型、卡介苗和两株对抗分枝杆菌药物完全耐药的偶然分枝杆菌的药敏实验室菌株进行了研究。87.8%的临床分离株对多种药物耐药。从一名接受环丙沙星治疗的患者中分离出两株结核分枝杆菌——一株对5微克/毫升左氧氟沙星耐药，另一株对10微克/毫升左氧氟沙星耐药。所有其他分枝杆菌临床和实验室菌株（97.8%）对三种浓度的左氧氟沙星均敏感。
