Vishnevskiĭ B I, Manicheva O A, Kocherovets V I
Antibiot Khimioter. 2005;50(12):16-8.
Drug susceptibility of 195 M. tuberculosis clinical isolates was tested with the indirect method of absolute concentrations on the Löwenstein-Jensen medium. 151 and 44 M. tuberculosis strains were isolated from patients with respiratory tract tuberculosis and tuberculosis of extrapulmonary localization respectivily. The resistance of the isolates to the main and reserve antituberculosis drugs amounted to 79.5%, including 62.1% of the isolates with multiple drug resistance. Levofloxacin was used in a concentration of 10 mcg/ml. The resistance to levofloxacin was detected only in 4 isolates from the patients with respiratory tract tuberculosis (2.05%), whereas the resistance to ofloxacin amounted to 11.8%.
采用绝对浓度间接法在罗-琴培养基上对195株结核分枝杆菌临床分离株进行药物敏感性检测。分别从呼吸道结核患者和肺外结核患者中分离出151株和44株结核分枝杆菌菌株。分离株对主要和备用抗结核药物的耐药率达79.5%，其中多重耐药分离株占62.1%。左氧氟沙星的使用浓度为10微克/毫升。仅在4株呼吸道结核患者分离株中检测到对左氧氟沙星的耐药性（2.05%），而对氧氟沙星的耐药率为11.8%。
