偏肺病毒与儿童急性喘息
Metapneumovirus and acute wheezing in children.
作者信息
Jartti Tuomas, van den Hoogen Bernadette, Garofalo Roberto P, Osterhaus Albert D M E, Ruuskanen Olli
机构信息
Department of Paediatrics, Turku University Hospital, PL 52, 20521, Turku, Finland.
出版信息
Lancet. 2002 Nov 2;360(9343):1393-4. doi: 10.1016/S0140-6736(02)11391-2.
A new respiratory virus, human metapneumovirus, was recently identified. We detected this virus by PCR in ten (8%) of 132 consecutive children admitted to Turku Hospital, Finland, for acute expiratory wheezing (median age 7 months, range 4-25). The mean duration of hospital stay was 2.5 days (SD 1.6) and mean duration of respiratory symptoms was 19 days (8). The white blood cell count, C-reactive protein, and regulated upon activation, normal T-cell-expressed and T-cell-secreted (RANTES) concentrations in nasal secretion remained low, whereas interleukin 8 concentrations in nasal secretion were high. Human metapneumovirus is a clinically important causative agent of acute wheezing in young children.
一种新型呼吸道病毒——人偏肺病毒，最近被发现。我们在芬兰图尔库医院连续收治的132例因急性呼气性喘息入院的儿童中，通过聚合酶链反应（PCR）检测到了这种病毒，其中10例（8%）检测呈阳性（中位年龄7个月，范围4 - 25个月）。平均住院时间为2.5天（标准差1.6），呼吸道症状的平均持续时间为19天（8天）。白细胞计数、C反应蛋白以及鼻腔分泌物中经激活调节的正常T细胞表达和T细胞分泌趋化因子（RANTES）浓度仍较低，而鼻腔分泌物中的白细胞介素8浓度较高。人偏肺病毒是幼儿急性喘息的一种临床上重要的病原体。
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