Jacobson Steven
Viral Immunology Section, Neuroimmunology Branch, National Institute of Neurological Disorders and Stroke/NIH, Bldg. 10, Rm. 5B-16, 9000 Rockville Pike, Bethesda, MD 20892, USA.
J Infect Dis. 2002 Dec 1;186 Suppl 2:S187-92. doi: 10.1086/344269.
This review focuses on current approaches to understanding the immunopathogenesis of human T cell lymphotropic virus (HTLV) type I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) based on newly developed molecular and immunologic techniques that have been adapted to studies of HTLV-I proviral load, HTLV-I mRNA, and HTLV-I tax-specific CD8 T cells. These methods enable researchers to study previously inaccessible aspects of this disease and allow a more detailed analysis of virus/host immune responses as they relate to disease specificity in this disorder. The role of HTLV-I-specific CD8 T cell immune responses is highlighted. The elucidation of the immunopathology of HAM/TSP will enhance our understanding of other HTLV-I-associated disorders plus other neurologic, hematologic, and inflammatory diseases for which viral etiologies have been suggested.
本综述聚焦于基于新开发的分子和免疫技术来理解I型人类嗜T细胞病毒（HTLV）相关脊髓病/热带痉挛性截瘫（HAM/TSP）免疫发病机制的当前方法，这些技术已应用于HTLV-I前病毒载量、HTLV-I mRNA和HTLV-I tax特异性CD8 T细胞的研究。这些方法使研究人员能够研究该疾病以前无法触及的方面，并能更详细地分析病毒/宿主免疫反应与该疾病特异性之间的关系。文中突出了HTLV-I特异性CD8 T细胞免疫反应的作用。对HAM/TSP免疫病理学的阐明将增进我们对其他HTLV-I相关疾病以及其他已提出病毒病因的神经、血液和炎症性疾病的理解。
