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人类嗜T淋巴细胞病毒1型（HTLV-1）是如何引发成人T细胞白血病/淋巴瘤（ATL）的？

How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?

作者信息

Bangham Charles R M, Ratner Lee

机构信息

Section of Virology, Department of Medicine, Imperial College, London W2 1PG, UK.

Medical Oncology Section, Hematology-Oncology Faculty, Washington University School of Medicine, St Louis, WA, USA.

出版信息

Curr Opin Virol. 2015 Oct;14:93-100. doi: 10.1016/j.coviro.2015.09.004. Epub 2015 Sep 27.

DOI:10.1016/j.coviro.2015.09.004
PMID:26414684
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4772697/
Abstract

A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.

摘要

感染逆转录病毒1型人类嗜T淋巴细胞病毒（HTLV-1）的典型患者携带数以万计的HTLV-1感染的T淋巴细胞克隆，每个克隆由前病毒在宿主基因组中的独特整合位点区分。然而，只有5%的感染者会发展为恶性疾病成人T细胞白血病/淋巴瘤，通常是在感染后50多年。我们综述了导致这种侵袭性疾病的宿主和病毒因素。

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TCF1 and LEF1 act as T-cell intrinsic HTLV-1 antagonists by targeting Tax.TCF1和LEF1通过靶向Tax发挥T细胞内在性HTLV-1拮抗剂的作用。
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