人类嗜T淋巴细胞病毒1型（HTLV-1）是如何引发成人T细胞白血病/淋巴瘤（ATL）的？
How does HTLV-1 cause adult T-cell leukaemia/lymphoma (ATL)?
作者信息
Bangham Charles R M, Ratner Lee
机构信息
Section of Virology, Department of Medicine, Imperial College, London W2 1PG, UK.
Medical Oncology Section, Hematology-Oncology Faculty, Washington University School of Medicine, St Louis, WA, USA.
出版信息
Curr Opin Virol. 2015 Oct;14:93-100. doi: 10.1016/j.coviro.2015.09.004. Epub 2015 Sep 27.
Abstract
A typical person infected with the retrovirus human T-lymphotropic virus type 1 (HTLV-1) carries tens of thousands of clones of HTLV-1-infected T lymphocytes, each clone distinguished by a unique integration site of the provirus in the host genome. However, only 5% of infected people develop the malignant disease adult T cell leukaemia/lymphoma, usually more than 50 years after becoming infected. We review the host and viral factors that cause this aggressive disease.
摘要
感染逆转录病毒1型人类嗜T淋巴细胞病毒（HTLV-1）的典型患者携带数以万计的HTLV-1感染的T淋巴细胞克隆，每个克隆由前病毒在宿主基因组中的独特整合位点区分。然而，只有5%的感染者会发展为恶性疾病成人T细胞白血病/淋巴瘤，通常是在感染后50多年。我们综述了导致这种侵袭性疾病的宿主和病毒因素。
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3
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Virology. 2015 Feb;476:271-288. doi: 10.1016/j.virol.2014.12.008. Epub 2015 Jan 5.
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