Allam Mohamed Farouk, Serrano del Castillo Amparo, Fernández-Crehuet Navajas Rafael
Department of Preventive Medicine and Public Health, Faculty of Medicine, University of Córdoba, Avda. Menéndez Pidal, s/n 14004 Córdoba, Spain.
Int J Neurosci. 2002 Jul;112(7):851-4. doi: 10.1080/00207450290025860.
A systematic review was conducted to estimate the pooled risk of smoking for Parkinson's disease in Chinese populations. The four identified case-control studies had odds ratios with 95% confidence intervals nearly or overlapping unity. Pooled odds ratio of these studies was 0.77 with 95% confidence interval 0.60 to 0.97. It was suggested that smoking induces debrisoquine 4-hydroxylase, which is responsible for the metabolism of antipsychotic drugs and the detoxification of certain environmental toxins known to cause dopaminergic neural damage. This could be the explanation of these contradictory results as cytochrome P-450 CYP2D6 debrisoquine hydroxylase gene polymorphism is known to be much lower in Chinese than in Caucasian people. This systematic review raises concerns about generalization of the conclusion previously settled by many cohort and case-control studies.
进行了一项系统综述，以评估中国人群中吸烟导致帕金森病的合并风险。纳入的四项病例对照研究的优势比及其95%置信区间接近或重叠于1。这些研究的合并优势比为0.77，95%置信区间为0.60至0.97。有研究表明，吸烟可诱导异喹胍4-羟化酶，该酶负责抗精神病药物的代谢以及某些已知会导致多巴胺能神经损伤的环境毒素的解毒。鉴于已知细胞色素P-450 CYP2D6异喹胍羟化酶基因多态性在中国人群中比在白种人中低得多，这可能是这些矛盾结果的解释。这项系统综述引发了人们对先前许多队列研究和病例对照研究所得出结论的普遍性的担忧。
